Research:
The group is currently focusing on:
- behavioral
tests;
- brain
oxidative stress and citotoxycity;
- assessment of cognitive processes using animal toxicological models (6-hydroxy-dopamine and beta-amyloid peptide);
- plants
used in herbal medicine; natural
products from plants – extraction and characterization;
- in-vitro oxidative stress and the stress defense mechanism; biochemical characterization of plant and animal extracts;
- antimicrobial testing; isolation and characterization of bacterial strains producing biological active compounds;
- proteins
purification and characterization;
- bioinformatics
(sequence analysis, protein structure prediction and in-silico docking);
- computational Biophysics; Molecular dynamics (NAMD; VMD)
Funding:
The group received funding for the fallowing grants:
- GI-UAIC-2022-08, Development and optimization of an extraction and purification method for 6-hydroxy-L-nicotine from the growth medium of Paenarthrobacter nicotinovorans, Coordinator - Boiangiu Răzvan Ștefan
- PN-III-P4-PCE-2021-1692, Antiaggregation potential of 6-hydroxy-L-nicotine from Paenarthrobacter nicotinovorans pAO1 against amyloid peptide: in vitro and in vivo studies (NICAGREG); Coordinator - Prof. Lucian Hrițcu
- PN-III-P4-ID-PCE-2020-0656, Sequencing the genome of a useful bacteria: Paenarthrobacter nicotinovorans – next step in extending it’s biotechnological applications; Coordinator - Prof. Marius Mihășan
- PN-III-P2-2.1-PED-2019-2235,
Tricyclic 1,3-dithiolium flavonoids - New weapons to
combat antibiotic resistance
(TriSflav); Coordinator - Prof. Marius Ștefan - PN-III-P3-3.1-PM-RO-FR-2019-0102, New synthetic flavonoids with antimicrobial applications (MICROFLAV); Coordinator - Prof. Marius Ștefan
- PN-III-P1-1.1-TE-2016-0367 - Developing an Arthrobacter nicotinovorans biotechnology for neuro-pharmaceuticals production; Coordinator - Assoc. Prof. Marius Mihășan
- PN-III-P2-2.1-PED-2016-0177
- Steps towards an Arthrobacter nicotinovorans
biotechnology for
neuro-pharmaceuticals production; Coordinator - Assoc. Prof. Marius Mihășan - PN-II 50BM/2016 - Romania - P.R.P. China joint research project: Nicotine - from toxic residue to metabolic derivatives with neuroprotective effects; Coordinator - Assoc. Prof. Marius Mihășan
- PN-II 10BM/2016 - Romania - South Africa joint research project: Study of Zea mays and Vigna unguiculata rhizosphere diversity – premises for potential applications in bioeconomy, Coordinator - Prof. Stefan Marius
- PN-II-RU-TE-2014-4-0106
- Effects of 6-hydroxy-nicotine on
chlorisondamine-induced oxidative
stress and neurotoxicity: relevance for Alzheimer’s disease; Coordinator - Assoc. Prof. Marius Mihășan - PN II – CAPACITĂȚI, Romania - France joint research project no. 780/30.06.2014 (2015-2016): Applications of some bio-molecules cu anti-fungal properties in plant protection, Coordinator - Prof. Stefan Marius
Contact
Identification and Characterization
of Biological Active Molecules Group
Adress : Faculty of Biology, Aelxandru I Cuza University of Iasi, Carol I B-vd., No. 20A, Iaşi, 700506, Romania
E-mail : please see the People
section
Phone : 40(0)232201072
Fax :
40(0)232201472
